Three years ago, she and her colleagues reported encouraging outcomes after allogeneic hematopoietic stem cell transplant (allo-HSCT) in relapsed or refractory PTCL: an overall survival rate of 61.7% and progression-free survival rate of 48.9% at 2 years. Mehta-Shah noted, aside from anaplastic large cell lymphomas, PTCL tends to have a poor prognosis. In bone marrow and stem cell transplantation, stem cells can be harvested (or collected) from various sources.As Dr. In an allogeneic transplant the stem cells are donated from another person, who is a genetically-matched stem cell donor. While all transplants are serious procedures, allogeneic transplants are more complicated and therefore carry more short and long-term risks than autologous transplants. The majority of these are autologous transplants. Almost 2,000 stem cell transplants are carried out in Australia each year. Autologous transplantsĪn autologous transplant uses the patient’s own stem cells, collected in advance and returned to them after they receive high doses of chemotherapy. Your doctor will spend time discussing with you and your family what he or she feels is the best option for you and your particular situation. For others a transplant is the only option that offers a prospect of cure, or long-term survival. In fact, many people don’t need a transplant and can be successfully treated using a less intensive approach. The transplant process is demanding both physically and emotionally, and some people may not be fit enough to tolerate it. These include the type of disease you have, your age, general health, the condition of your marrow and whether you would benefit by receiving donated stem cells, or whether your own stem cells can be used.Ī stem cell transplant is not necessarily the best option for everyone. The type of transplant you are given depends on a number of factors. There are two main types of transplants: autologous transplants and allogeneic transplants. The new blood stem cells will rebuild your body’s blood and immune systems. In short, a stem cell transplant is necessary to ensure that the bone marrow is repopulated with healthy blood stem cells following high-dose treatment. Sometimes stem cells also need to be replaced because they are diseased (for example in leukaemia) or defective (for example in aplastic anaemia). High-dose chemotherapy aims to destroy disease but, as an unwanted effect, it may also destroy the precious blood stem cells, which then need to be replaced. They divide and mature into all the different types of blood cells (red cells, white cells and platelets), including the cells of our immune system and are therefore vital for our survival. These stem cells can be likened to ‘baby’ cells that have not yet decided which type of blood cell they want to be when they grow up. Stem cells are primitive blood-forming cells that normally live in the bone marrow.
some immune system disorders (for example scleroderma).some solid tumours (for example testicular cancer, breast cancer).
These include haematological (blood) disease such as leukaemia, as well as non-haematological diseases. The following list gives you some examples of conditions which can be treated with stem cell transplantation:
Bone marrow and blood stem cell transplantation (commonly referred to as simply stem cell transplantation) is used to treat a range of diseases.
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